Addiction is a treatable, chronic medical disease involving complex interactions among brain circuits, genetics, the environment, and an individual’s life experiences. People with addiction use substances or engage in behaviors that become compulsive and often continue despite harmful consequences, according to the American Society of Addiction Medicine (ASAM).
Opioid use disorder is a significant public health crisis in America today.1
Opioid overdose is the leading cause of death for Americans under the age of 50.2
Each day in the US, 128 people die from opioid-related causes.3
More than 67,000 Americans died from drug overdoses in 2018, most involving an opioid like fentanyl, heroin or oxycodone.3
The true cost of the opioid drug epidemic in 2015 was $504 billion, or roughly half a trillion dollars, according to the U.S. Council of Economic Advisers.4
In 2015, there were 690,000 OUD ICU admissions with an average cost of $92,400 per patient, totaling an average cost to payers of $63.8B.5
Buprenorphine is an FDA-approved medication that can help treat opioid use disorder. It binds to opioid receptors and effectively blocks the signals from other opioids. Currently, oral buprenorphine is the most commonly used form of buprenorphine-based medication therapy for the treatment of OUD. Patients receiving oral buprenorphine typically receive daily oral buprenorphine or buprenorphine/naloxone combination products (either tablets or sublingual film). These formulations are self-administered. Braeburn is developing a long-acting formulation of buprenorphine to treat OUD.
1 Katz, J. (2017, June 05). Drug Deaths in America Are Rising Faster Than Ever. Retrieved December 17, 2018. from: https://www.nytimes.com/interactive/2017/06/05/upshot/opioid-epidemic-drug-overdose-deaths-are-rising-faster-than-ever.html
2 Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2018 on CDC WONDER Online Database, released in 2020. Accessed at http://wonder.cdc.gov/ucd-icd10.html on Jul 1, 2020.
3NCHS, National Vital Statistics System, Mortality. Accessed at https://www.cdc.gov/nchs/data/databriefs/db356_tables-508.pdf#3 on Jul 1, 2020.
4 The Council of Economic Advisors, November 2017. The Underestimated Cost of the Opioid Crisis. Accessed on January 18, 2018, https://www.whitehouse.gov/sites/whitehouse.gov/files/images/The%20Underestimated%20Cost%20of%20the%20Opioid%20Crisis.pdf
5 Stevens et al, 2017, Annals of the American Thoracic Society